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- Title
Cytomegalovirus seropositivity is negatively associated with multiple sclerosis.
- Authors
Sundqvist, E; Bergström, T; Daialhosein, H; Nyström, M; Sundström, P; Hillert, J; Alfredsson, L; Kockum, I; Olsson, T
- Abstract
Background: Epidemiological data suggest a role for common viruses in the pathogenesis of multiple sclerosis (MS), andrecent data showed a negative association of past cytomegalovirus (CMV) infection on pediatric MS risk.Objective: Our aim was to analyze the association of CMV infection with MS risk in an adult case-control material. Ameta-analysis was performed to validate our findings.Methods: Epidemiological Investigation in MS (EIMS) is a case-control study with incident cases and population-basedcontrols. Anti-CMV antibody titers were measured with ELISA, and HLA-A and DRB1 genotyping was performed withSSP-PCR, in 658 MS cases, who all fulfilled the McDonald criteria for MS, and 786 controls.Results: CMV seropositivity was associated with a decreased MS risk, OR = 0.73 (0.58–0.92 95% CI), p = 0.005,adjusted for index age, gender, smoking, sun exposure, EBNA1 IgG titer and HLA-A*02 and DRB1*15. When we removedall cases and controls younger than 18 years at index, the protective effect was still apparent.Conclusions: CMV is negatively associated with adult-onset MS pathology, consistent with results from a study onpediatric MS cases. It remains to be shown whether this negative association is due to a true protective effect of CMVinfection on MS risk.
- Subjects
CYTOMEGALOVIRUS diseases; MULTIPLE sclerosis research; DEMYELINATION; VIRUS diseases; CASE-control method
- Publication
Multiple Sclerosis Journal, 2014, Vol 20, Issue 2, p165
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/1352458513494489