Back to matchesWe found a matchYour institution may have rights to this item. Sign in to continue.TitlePathophysiological role of endothelin revealed by the first orally active endothelin receptor...AuthorsClozel, Martine; Breu, VolkerAbstractPresents evidence for the pathophysiological role of endothelin-1 as brought by the first synthetic orally active non-peptide antagonist of endothelin receptors, Ro 46-2005. Vasoconstrictor effect of endothelin-1; Endothelin-1 as a paracrine factor.SubjectsENDOTHELINSPublicationNature, 1993, Vol 365, Issue 6448, p759ISSN0028-0836Publication typeArticleDOI10.1038/365759a0