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Chemical modification: the key to clinical application of RNA interference?
- Published in:
- Journal of Clinical Investigation, 2007, v. 117, n. 12, p. 3615, doi. 10.1172/JCI33483
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- Article
Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs.
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- Nucleic Acids Research, 2018, v. 46, n. 4, p. 1584, doi. 10.1093/nar/gkx1239
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- Article
Editorial: Nucleic Acids Research and Nucleic Acid Therapeutics.
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- Nucleic Acids Research, 2018, v. 46, n. 4, p. 1563, doi. 10.1093/nar/gky059
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- Article
Regulation of mammalian transcription and splicing by Nuclear RNAi.
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- Nucleic Acids Research, 2016, v. 44, n. 2, p. 524, doi. 10.1093/nar/gkv1305
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- Publication type:
- Article
Intramolecular circularization increases efficiency of RNA sequencing and enables CLIP-Seq of nuclear RNA from human cells.
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- Nucleic Acids Research, 2015, v. 43, n. 11, p. 1, doi. 10.1093/nar/gkv213
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- Article
Design and bioinformatics analysis of genome-wide CLIP experiments.
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- Nucleic Acids Research, 2015, v. 43, n. 11, p. 5263, doi. 10.1093/nar/gkv439
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- Article
Breakthrough Articles: Putting science first.
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- Nucleic Acids Research, 2014, v. 42, n. 18, p. 11273, doi. 10.1093/nar/gku853
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- Article
Promoter RNA links transcriptional regulation of inflammatory pathway genes.
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- Nucleic Acids Research, 2013, v. 41, n. 22, p. 10086, doi. 10.1093/nar/gkt777
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- Publication type:
- Article
ss-siRNAs allele selectively inhibit ataxin-3 expression: multiple mechanisms for an alternative gene silencing strategy.
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- Nucleic Acids Research, 2013, v. 41, n. 20, p. 9570, doi. 10.1093/nar/gkt693
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- Publication type:
- Article
RNA duplexes with abasic substitutions are potent and allele-selective inhibitors of huntingtin and ataxin-3 expression.
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- Nucleic Acids Research, 2013, v. 41, n. 18, p. 8788, doi. 10.1093/nar/gkt594
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- Publication type:
- Article
Mechanism of allele-selective inhibition of huntingtin expression by duplex RNAs that target CAG repeats: function through the RNAi pathway.
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- Nucleic Acids Research, 2012, v. 40, n. 22, p. 11270, doi. 10.1093/nar/gks907
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- Article
Expanding the action of duplex RNAs into the nucleus: redirecting alternative splicing.
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- Nucleic Acids Research, 2012, v. 40, n. 3, p. 1240, doi. 10.1093/nar/gkr780
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- Article
Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters.
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- Nucleic Acids Research, 2011, v. 39, n. 13, p. 5682, doi. 10.1093/nar/gkr155
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- Publication type:
- Article
Involvement of argonaute proteins in gene silencing and activation by RNAs complementary to a non-coding transcript at the progesterone receptor promoter.
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- Nucleic Acids Research, 2010, v. 38, n. 21, p. 7736, doi. 10.1093/nar/gkq648
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- Publication type:
- Article
Effect of chemical modifications on modulation of gene expression by duplex antigene RNAs that are complementary to non-coding transcripts at gene promoters.
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- Nucleic Acids Research, 2010, v. 38, n. 15, p. 5242, doi. 10.1093/nar/gkq258
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- Publication type:
- Article
Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs.
- Published in:
- Nature Biotechnology, 2009, v. 27, n. 5, p. 478, doi. 10.1038/nbt.1539
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- Publication type:
- Article
Silencing disease genes in the laboratory and the clinic.
- Published in:
- Journal of Pathology, 2012, v. 226, n. 2, p. 365, doi. 10.1002/path.2993
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- Publication type:
- Article
Allele-Selective Inhibition of Mutant Huntingtin by Peptide Nucleic Acid-Peptide Conjugates, Locked Nucleic Acid, and Small Interfering RNA.
- Published in:
- Annals of the New York Academy of Sciences, 2009, v. 1175, n. 1, p. 24, doi. 10.1111/j.1749-6632.2009.04975.x
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- Article
Antisense transcripts are targets for activating small RNAs.
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- Nature Structural & Molecular Biology, 2008, v. 15, n. 8, p. 842, doi. 10.1038/nsmb.1444
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- Publication type:
- Article
Involvement of AGO1 and AGO2 in mammalian transcriptional silencing.
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- Nature Structural & Molecular Biology, 2006, v. 13, n. 9, p. 787, doi. 10.1038/nsmb1140
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- Publication type:
- Article
Recognition of Chromosomal DNA in Human Cells by Peptide Nucleic Acids and Small Duplex RNAs.
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- Annals of the New York Academy of Sciences, 2005, v. 1058, n. 1, p. 16, doi. 10.1196/annals.1359.003
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- Article
Imaging gene expression using oligonucleotides and peptide nucleic acids.
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- Journal of Cellular Biochemistry, 2003, v. 90, n. 3, p. 437, doi. 10.1002/jcb.10626
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- Article
Telomerase inhibition, oligonucleotides, and clinical trials.
- Published in:
- Oncogene, 2002, v. 21, n. 4, p. 631, doi. 10.1038/sj.onc.1205063
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- Publication type:
- Article
Regulation of TFEB and V-ATPases by mTORC1.
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- EMBO Journal, 2011, v. 30, n. 16, p. 3242, doi. 10.1038/emboj.2011.257
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- Article
Doubts About Therapy for Neurological Diseases With Antisense Oligonucleotides.
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- JAMA Neurology, 2016, v. 73, n. 12, p. 1502, doi. 10.1001/jamaneurol.2016.4335
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- Article
Synthetic Nucleic Acids and Treatment of Neurological Diseases.
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- JAMA Neurology, 2016, v. 73, n. 10, p. 1238, doi. 10.1001/jamaneurol.2016.2089
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- Article
Telomerase inhibition by peptide nucleic acids reverses `immortality' of transformed human cells.
- Published in:
- Oncogene, 1999, v. 18, n. 46, p. 6191, doi. 10.1038/sj.onc.1203069
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- Publication type:
- Article
Antisense inhibition of gene expression in cells by oligonucleotides incorporating locked nucleic acids: effect of mRNA target sequence and chimera design.
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- Nucleic Acids Research, 2002, v. 30, n. 23, p. 5160, doi. 10.1093/nar/gkf651
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- Publication type:
- Article
DNA assembly using bis-peptide nucleic acids (bisPNAs).
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- Nucleic Acids Research, 2002, v. 30, n. 13, p. 2782, doi. 10.1093/nar/gkf389
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- Publication type:
- Article
Non-Watson–Crick interactions between PNA and DNA inhibit the ATPase activity of bacteriophage T4 Dda helicase.
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- Nucleic Acids Research, 2002, v. 30, n. 4, p. 950, doi. 10.1093/nar/30.4.950
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- Article
Strand invasion by mixed base PNAs and a PNA–peptide chimera.
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- Nucleic Acids Research, 2000, v. 28, n. 17, p. 3332, doi. 10.1093/nar/28.17.3332
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- Article
Activating frataxin expression by repeat-targeted nucleic acids.
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- Nature Communications, 2016, v. 7, n. 2, p. 10606, doi. 10.1038/ncomms10606
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- Article
Telomerase enzyme inhibition (TEI) and cytolytic therapy in the management of androgen independent osseous metastatic prostate cancer.
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- Prostate, 2010, v. 70, n. 6, p. 616, doi. 10.1002/pros.21096
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- Article
Oligonucleotides targeting TCF4 triplet repeat expansion inhibit RNA foci and mis-splicing in Fuchs’ dystrophy.
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- Human Molecular Genetics, 2018, v. 27, n. 6, p. 1015, doi. 10.1093/hmg/ddy018
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- Publication type:
- Article
Reduced Expression of Argonaute 1, Argonaute 2, and TRBP Changes Levels and Intracellular Distribution of RNAi Factors.
- Published in:
- Scientific Reports, 2015, p. 12855, doi. 10.1038/srep12855
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- Article
Nuclear localization of Argonaute 2 is affected by cell density and may relieve repression by microRNAs.
- Published in:
- Nucleic Acids Research, 2024, v. 52, n. 4, p. 1930, doi. 10.1093/nar/gkad1155
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- Article
Editorial: Nucleic Acids Research virtual issue dedicated to nucleic acid therapeutics, 2018–2023.
- Published in:
- 2024
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- Publication type:
- Editorial
Editorial: Critical reviews and perspectives in Nucleic Acids Research.
- Published in:
- Nucleic Acids Research, 2022, v. 50, n. 13, p. 7201, doi. 10.1093/nar/gkac598
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- Article
Reexamining assumptions about miRNA-guided gene silencing.
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- Nucleic Acids Research, 2022, v. 50, n. 2, p. 617, doi. 10.1093/nar/gkab1256
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- Article
Targeting 3′ and 5′ untranslated regions with antisense oligonucleotides to stabilize frataxin mRNA and increase protein expression.
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- Nucleic Acids Research, 2021, v. 49, n. 20, p. 11560, doi. 10.1093/nar/gkab954
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- Article
Argonaute binding within 3′-untranslated regions poorly predicts gene repression.
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- Nucleic Acids Research, 2020, v. 48, n. 13, p. 7439, doi. 10.1093/nar/gkaa478
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- Article
Analyzing pre-symptomatic tissue to gain insights into the molecular and mechanistic origins of late-onset degenerative trinucleotide repeat disease.
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- Nucleic Acids Research, 2020, v. 48, n. 12, p. 6740, doi. 10.1093/nar/gkaa422
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- Article
The structure of a Michaelis serpin?protease complex.
- Published in:
- Nature Structural Biology, 2001, v. 8, n. 11, p. 979, doi. 10.1038/nsb1101-979
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- Publication type:
- Article
Analysis of nuclear RNA interference in human cells by subcellular fractionation and Argonaute loading.
- Published in:
- Nature Protocols, 2014, v. 9, n. 9, p. 2045, doi. 10.1038/nprot.2014.135
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- Article
Transcriptional regulation by small RNAs at sequences downstream from 3′ gene termini.
- Published in:
- Nature Chemical Biology, 2010, v. 6, n. 8, p. 621, doi. 10.1038/nchembio.400
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- Publication type:
- Article
Activating gene expression in mammalian cells with promoter-targeted duplex RNAs.
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- Nature Chemical Biology, 2007, v. 3, n. 3, p. 166, doi. 10.1038/nchembio860
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- Publication type:
- Article
RNA learns from antisense.
- Published in:
- Nature Chemical Biology, 2007, v. 3, n. 1, p. 8, doi. 10.1038/nchembio0107-8
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- Publication type:
- Article
Inhibiting transcription of chromosomal DNA with antigene peptide nucleic acids.
- Published in:
- Nature Chemical Biology, 2005, v. 1, n. 4, p. 210, doi. 10.1038/nchembio724
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- Publication type:
- Article
Inhibiting gene expression at transcription start sites in chromosomal DNA with antigene RNAs.
- Published in:
- Nature Chemical Biology, 2005, v. 1, n. 4, p. 216, doi. 10.1038/nchembio725
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- Publication type:
- Article
The Puzzle of RNAs that Target Gene Promoters.
- Published in:
- ChemBioChem, 2009, v. 10, n. 7, p. 1135, doi. 10.1002/cbic.200900015
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- Article