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- Title
Modulation of Lymphocyte Receptor Redistribution by Concanavalin A, Anti-mitotic Agents and Alterations of pH.
- Authors
YAHARA, I.; EDELMAN, G. M.
- Abstract
VARIOUS lymphocyte surface receptors can be redistributed after cross linkage by external ligands, leading to the formation of patches and caps1. At 21° C and 37° C concanavalin A (con A) in concentrations greater than 5 µg ml−1 inhibits patch and subsequent cap formation induced by anti-immunoglobulin and other reagents2,3. Con A can also induce cap formation by its own receptors under certain conditions, notably after binding at 4° C3,4. Thus con A has two antagonistic activities in modulating lymphocyte surface receptor distribution and their expression depends on the conditions of incubation. We now report results suggesting that colchicine-binding proteins5 (possibly those of the microtubules) are important in the modulation of cell surface mobility. In addition, we have found that alterations of pH affect the ability of lymphocytes to form patches and caps.
- Publication
Nature, 1973, Vol 246, Issue 5429, p152
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/246152a0