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- Title
Pacing interventions in non-responders to cardiac resynchronization therapy.
- Authors
Wijesuriya, Nadeev; Elliott, Mark K.; Mehta, Vishal; De Vere, Felicity; Strocchi, Marina; Behar, Jonathan M.; Niederer, Steven A.; Rinaldi, Christopher A.
- Abstract
Non-responders to Cardiac Resynchronization Therapy (CRT) represent a high-risk, and difficult to treat population of heart failure patients. Studies have shown that these patients have a lower quality of life and reduced life expectancy compared to those who respond to CRT. Whilst the first-line treatment for dyssynchronous heart failure is "conventional" biventricular epicardial CRT, a range of novel pacing interventions have emerged as potential alternatives. This has raised the question whether these new treatments may be useful as a second-line pacing intervention for treating non-responders, or indeed, whether some patients may benefit from these as a first-line option. In this review, we will examine the current evidence for four pacing interventions in the context of treatment of conventional CRT nonresponders: CRT optimization; multisite left ventricular pacing; left ventricular endocardial pacing and conduction system pacing.
- Subjects
CARDIAC pacing; HEART failure; HEART failure patients; LIFE expectancy
- Publication
Frontiers in Physiology, 2023, Vol 14, p1
- ISSN
1664-042X
- Publication type
Article
- DOI
10.3389/fphys.2023.1054095