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- Title
Priming exercise accelerates oxygen uptake kinetics during high-intensity cycle exercise in middle-aged individuals with type 2 diabetes.
- Authors
Rocha, Joel; Gildea, Norita; O'Shea, Donal; Green, Simon; Egaña, Mikel
- Abstract
Background: The primary phase time constant of pulmonary oxygen uptake kinetics (VO2 Tp) during submaximal efforts is longer inmiddle-aged peoplewith type 2 diabetes (T2D), partly due to limitations in oxygen supply to active muscles. This study examined if a high-intensity "priming" exercise (PE) would speed VO2 Tp during a subsequent high-intensity cycling exercise in T2D due to enhanced oxygen delivery. Methods: Eleven (4 women) middle-aged individuals with type 2 diabetes and 11 (4 women) non-diabetic controls completed four separate cycling bouts each starting at an 'unloaded' baseline of 10W and transitioning to a high-intensity constant-load. Two of the four cycling bouts were preceded by priming exercise. The dynamics of pulmonary VO2 and muscle deoxygenation (i.e. deoxygenated haemoglobin and myoglobin concentration [HHb + Mb]), were calculated from breath-by-breath and near-infrared spectroscopy data at the vastus lateralis, respectively. Results: At baseline VO2 Tp, was slower ( < 0.001) in the type 2 diabetes group (48 ± 6 s) compared to the control group (34 ± 2 s) but priming exercise significantly reduced VO2 Tp ( < 0.001) in type 2 diabetes (32 ± 6 s) so that post priming exercise itwas not different comparedwith controls (34 ± 3 s). Priming exercise reduced the amplitude of the VO2 slow component (As)inbothgroups (type 2 diabetes: 0.26 ± 0.11 to 0.16 ± 0.07 L/min; control: 0.33 ± 0.13 to 0.25 ± 0.14 L/min, < 0.001), while [HHb + Mb] kinetics remained unchanged. Conclusion: These results suggest that in middle-aged men and women with T2D, PE speeds VO2 Tp likely by a better matching of O2 delivery to utilisation and reduces the VO2 As during a subsequent high-intensity exercise.
- Subjects
TYPE 2 diabetes; CYCLING; MIDDLE-aged men; NEAR infrared spectroscopy; VASTUS lateralis
- Publication
Frontiers in Physiology, 2022, Vol 13, p01
- ISSN
1664-042X
- Publication type
Article
- DOI
10.3389/fphys.2022.1006993