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- Title
Acute exercise reduces feeding by activating IL-6/Tubby axis in the mouse hypothalamus.
- Authors
de Oliveira Micheletti, Thayana; Cassia dos Santos, Andressa; Zweig Rocha, Guilherme; Silva, Vagner Ramon Rodrigues; Quaresma, Paula Gabriele Fernandes; Balan Assalin, Heloisa; Silva Junqueira, Felipe; Rochete Ropelle, Eduardo; Gabarra Oliveira, Alexandre; Abdalla Saad, Mario Jose; de Oliveira Prada, Patricia
- Abstract
Background: Acute exercise contributes to decreased feeding through leptin and interleukin/Janus kinase 2/signal transducers and activators of transcription 3 (IL-6/JAK2/STAT3) signaling. Considering the pleiotropic use of substrates by JAK2 and that JAK2 can phosphorylate the Tubby protein (TUB) in CHO-IR cells, we speculated that acute exercise can activate the IL-6/JAK2/TUB pathway to decrease food intake. Aims: We investigated whether acute exercise induced tyrosine phosphorylation and the association of TUB and JAK2 in the hypothalamus and if IL-6 is involved in this response, whether acute exercise increases the IL- 6/TUB axis to regulate feeding, and if leptin has an additive effect over this mechanism. Methods: We applied a combination of genetic, pharmacological, and molecular approaches. Key findings: The in vivo experiments showed that acute exercise increased the tyrosine phosphorylation and association of JAK2/TUB in the hypothalamus, which reduced feeding. This response was dependent on IL-6. Leptin had no additive effect on this mechanism. Significance: The results of this study suggest a novel hypothalamic pathway by which IL-6 released by exercise regulates feeding and reinforces the beneficial effects of exercise.
- Subjects
LEPTIN; REDUCING exercises; HYPOTHALAMUS; FOOD consumption; MICE; INTERLEUKIN-6
- Publication
Frontiers in Physiology, 2022, Vol 13, p1
- ISSN
1664-042X
- Publication type
Article
- DOI
10.3389/fphys.2022.956116