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- Title
The m<sup>6</sup>A-ncRNAs axis in diabetes complications: novel mechanism and therapeutic potential.
- Authors
Siming Yu; Chunsheng Li; Xinxin Lu; Zehui Han; Yue Li; Xingxing Yuan; Dandan Guo
- Abstract
Diabetes, a multifaceted metabolic disorder, poses a significant global health burden with its increasing prevalence and associated complications, such as diabetic nephropathy, diabetic retinopathy, diabetic cardiomyopathy, and diabetic angiopathy. Recent studies have highlighted the intricate interplay between N6-methyladenosine (m6A) and non-coding RNAs (ncRNAs) in key pathways implicated in these diabetes complications, like cell apoptosis, oxidative stress, and inflammation. Thus, understanding the mechanistic insights into how m6A dysregulation impacts the expression and function of ncRNAs opens new avenues for therapeutic interventions targeting the m6AncRNAs axis in diabetes complications. This review explores the regulatory roles ofm6A modifications and ncRNAs, and stresses the role of them6A-ncRNA axis in diabetes complications, providing a therapeutic potential for these diseases.
- Subjects
DIABETES complications; DIABETIC cardiomyopathy; METABOLIC disorders; NON-coding RNA; ADENOSINES; DIABETIC nephropathies; DIABETIC retinopathy
- Publication
Frontiers in Endocrinology, 2024, p1
- ISSN
1664-2392
- Publication type
Article
- DOI
10.3389/fendo.2024.1426380