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- Title
Evaluation of micelles incorporated into thermosensitive hydrogels for intratumoral delivery and controlled release of docetaxel: A dual approach for in situ treatment of tumors.
- Authors
Meng Xu; Yanhua Mou; Mingming Hu; Wenxiang Dong; Xitong Su; Rongxia Wu; Peng Zhang
- Abstract
The in situ gelling hybrid hydrogel system has been reported to effectively concentrate chemotherapeutic drugs at the tumor site and sustain their release for a long period. DTXmicelles (docetaxel-loaded mixed micelles) are able to increase the solubility of DTX in water, and then a high drug loading rate of hydrogels can be achieved by encapsulating the docetaxel-loaded mixed micelles into the hydrogels. The thermosensitive nature of DTX-MM-hydrogels (thermosensitive hydrogels incorporated with docetaxel-loaded mixed micelles) can accelerate the formation of a depot of this drug-loaded system at the site of administration. Therefore, the hydrogels provide a much slower release compared with DTX-micelles and DTX-injection. An in vivo retention study has demonstrated that the DTXMM- hydrogels can prolong the drug retention time and in viv o trials have shown that the DTX-MM-hydrogels have a higher antitumor efficacy and systemic safety. In conclusion, the DTX-MM-hydrogels prepared in this study have considerable potential as a drug delivery system, with higher tumor inhibition effects and are less toxic to normal tissues.
- Subjects
MICELLES; HYDROGELS; DOCETAXEL; CANCER chemotherapy; TREATMENT effectiveness
- Publication
Asian Journal of Pharmaceutical Sciences, 2018, Vol 13, Issue 4, p373
- ISSN
1818-0876
- Publication type
Article
- DOI
10.1016/j.ajps.2018.05.004