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- Title
Association between SOX17, Wif-1 and RASSF1A promoter methylation status and response to chemotherapy in patients with metastatic gastric cancer.
- Authors
Karamitrousis, Evangelos; Balgkouranidou, Ioanna; Xenidis, Nikolaos; Amarantidis, Kyriakos; Biziota, Eirini; Koukaki, Triantafyllia; Trypsianis, Gregorios; Karayiannakis, Anastasios; Bolanaki, Heleni; Chatzaki, Ekaterini; Kolios, Georgios; Lianidou, Evi; Lambropoulou, Maria; Kakolyris, Stylianos
- Abstract
In the present group, the promoter of I SOX17 i gene was methylated in 61 out of 105 patients (58.1%), the promoter of the I Wi i f-1 gene was methylated in 34 out of 105 patients (32.4%) and the promoter of the I RASSF1A i gene was methylated in 68 out of 105 patients (64.8%). These genes are major tumor suppressor genes, often methylated in gastric cancer. Moreover, there was a tendency toward disease progression of the disease when the promoter of I Wi i f-1 gene was unmethylated, in contrast to the results for the I SOX17 i and I RASSF1A i genes.
- Subjects
STOMACH cancer; METASTASIS; METHYLATION; PROMOTERS (Genetics); TUMOR suppressor proteins
- Publication
Clinical Chemistry & Laboratory Medicine, 2021, Vol 59, Issue 1, pe73
- ISSN
1434-6621
- Publication type
Article
- DOI
10.1515/cclm-2020-0662