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- Title
CDH1 (E-cadherin) expression independently affects clinical outcome in acute myeloid leukemia with normal cytogenetics.
- Authors
Ting-juan Zhang; Jing-dong Zhou; Ji-chun Ma; Zhao-qun Deng; Zhen Qian; Dong-ming Yao; Jing Yang; Xi-xi Li; Jiang Lin; Jun Qian
- Abstract
Background: Epithelial-mesenchymal transition (EMT) is a critical process which involves in tumor metastasis. As an important EMT marker gene, CDH1 (E-cadherin) expression and its clinical implication in acute myeloid leukemia (AML) remain largely elusive. Methods: Real-time quantitative PCR (RQ-PCR) was carried out to examine CDH1 transcript level in 123 de novo AML patients and 34 controls. Results: Compared with controls, CDH1 was significantly downregulated in AML (p < 0.001). The median level of CDH1 expression divided total AML patients into CDH1 low-expressed (CDH11ow) and CDH1 high-expressed (CDH1high) groups. There were no significant differences between the two groups in age, peripheral blood cell counts, complete remission (CR) rate, and the distribution of FAB/WHO subtypes as well as karyotypes/karyotypic classifications (p > 0.05). However, CDH11ow group tended to have a higher bone marrow (BM) blasts (p = 0.093). The spearman correlation analysis further illustrated a trend towards a negative correlation between CDH1 expression level and BM blasts (r = -0.214, p = 0.052). CDH1low group had a tendency towards a lower frequency of N/K-RAS mutations (p = 0.094). Furthermore, CDH1low patients had markedly shorter overall survival (OS) time in cytogenetic normal AML (CN-AML) (p = 0.019). Both univariate and multivariate analyses confirmed the prognostic value of CDH1 expression in CN-AML patients (p = 0.027 and 0.033, respectively). Conclusions: CDH1 downregulation acted as an independent prognostic biomarker in CN-AML patients.
- Subjects
MYELOID leukemia; LEUKEMIA treatment; GENE expression; THERAPEUTIC use of biochemical markers; CADHERINS; CYTOGENETICS; GENETICS
- Publication
Clinical Chemistry & Laboratory Medicine, 2017, Vol 55, Issue 1, p123
- ISSN
1434-6621
- Publication type
Article
- DOI
10.1515/cclm-2016-0205