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- Title
Lipoprotein-associated phospholipase A<sub>2</sub> is elevated in patients with severe aortic valve stenosis without clinically overt atherosclerosis.
- Authors
Kolasa-Trela, Renata; Fil, Korneliusz; Bazanek, Marta; Grudzień, Grzegorz; Sobczyk, Dorota; Sadowski, Jerzy; Undas, Anetta
- Abstract
Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an inflammatory mediator involved in atherosclerosis. Since aortic valve stenosis (AVS) is regarded as an atherosclerosis-like inflammatory disease, we sought to investigate whether AVS is associated with elevated Lp-PLA2. Methods: Plasma Lp-PLA2 levels were determined in 48 consecutive patients with severe AVS without atherosclerotic vascular disease and compared with the values obtained in 48 controls matched for age, sex and cardiovascular risk factors. Results: Lp-PLA2 was higher in AVS than in controls (242.3±50.4 vs. 151.9±28.1 ng/mL, p<0.0001). Lp-PLA2 correlated inversely with aortic valve area (AVA) (r=-0.53; p=0.0001) and positively with mean pressure gradient (PG) (r=0.32; p=0.029). In multivariable analysis C-reactive protein (CRP) (OR=1.42; 95% CI 0.95-2.1; p=0.09) and AVA (OR=0.003; 95% CI 0.00004-0.23; p<0.01) were independently associated with Lp-PLA2 above a mean of 242 ng/mL. After adjustment for CRP, AVA was the only independent predictor of Lp-PLA2 in AVS patients (p<0.001). Conclusions: This study is the first to show that AVS is characterized by increased plasma Lp-PLA2 levels associated with the severity of AVS, which suggests active involvement of Lp-PLA2 in the pathogenesis of AVS.
- Subjects
LIPOPROTEINS; PHOSPHOLIPASE A2; AORTIC stenosis; CARDIOVASCULAR diseases risk factors; CONTROL groups; BLOOD plasma
- Publication
Clinical Chemistry & Laboratory Medicine, 2012, Vol 50, Issue 10, p1825
- ISSN
1434-6621
- Publication type
Article
- DOI
10.1515/cclm-2012-0015