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- Title
Sudoriferous acrosyringeal acantholytic disease.
- Authors
Hashimoto, Ken; Moiin, Ali; Chang, Mary Wu; Tada, Joji
- Abstract
Three selected cases of transient acantholytic dermatosis were studied because of their definitive correlation with sweating due to fever and/or bed-ridden situations. Biopsy specimens were serially sectioned and acantholysis was found in the acrosyringium or traced to connect to the acrosyringium in all biopsy specimens. Carcinoembryonic antigen (CEA) and eccrine gland-specific monoclonal antibody, IKH-4, were positive in acantholytic cells. Electron microscopy revealed electron dense material filling the lumen of intraepidermal eccrine ducts. This material leaked into lateral intercellular spaces of the luminal cells, passing tight junctions. Marked edema and numerous lysosomes were reminiscent of those found when eccrine acrosyringium is formed in the embryo, this suggested that an occluded and damaged eccrine intraepidermal duct, was being rebuilt via lysosomal digestion.
- Subjects
SWEATING-sickness; CARCINOEMBRYONIC antigen; CASE studies; BIOPSY; MONOCLONAL antibodies; EDEMA
- Publication
Journal of Cutaneous Pathology, 1996, Vol 23, Issue 2, p151
- ISSN
0303-6987
- Publication type
Article
- DOI
10.1111/j.1600-0560.1996.tb01289.x