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- Title
Clinical and demographical features of autoimmune bullous diseases: a retrospective analysis of 85 patients.
- Authors
Gül, Ülker; Kılıç, Arzu; Külcü Çakmak, Seray; Soylu, Seçil; Gönül, Müzeyyen
- Abstract
Summary Background and Design: Autoimmune bullous dermatoses are a group of diseases characterized by the presence of autoantibodies in tissue or blood against specific cutaneous antigens. The aim of our study was to evaluate the demographical and clinical features of patients with autoimmune bullous diseases who applied to our clinic. Materials and Methods: We retrospectively analyzed the patients who were diagnosed with autoimmune bullous diseases according to clinical, histopathological and immunopathological criteria between the years 2003 and 2011. The subjects were evaluated according to their sex, age, the type of autoimmune bullous disease, the onset and localization of lesions, the extensity of involvement, associated diseases, the treatment they were given and the response to the treatment. Results: A total of 85 cases were included in our study. Forty-nine (57.64%) patients were female, 36 (42.36%) were male. Fifty-seven cases (67.05%) belonged to pemphigus (P) group and 24 (28.23%) to pemphigoid. The ratio of patients with pemphigus vulgaris to the patients with pemphigoid was found to be 3.16. The age range of the onset of the symptoms was between 22 and 82 years old. The duration of the lesions was between 2 weeks and 120 months. On follow up, a patient with pemphigus vulgaris was diagnosed as having gastric carcinoma. Bone metastasis was detected in one patient with bullous pemphigoid who was operated for breast carcinoma previously. Renal cell carcinoma and lymphoma were detected in two patients with bullous pemphigoid. All patients, except one, responded to therapy. Conclusion: In our study, the frequent disease was P.vulgaris, but the ratio of pemphigus/bullous pemphigoid was found to be lower than previous studies. Besides, we want to emphasize that detailed investigations due to the possibility of the presence with other diseases.
- Publication
Archives of the Turkish Dermatology & Venerology / Turkderm, 2014, Vol 48, Issue 1, p7
- ISSN
1019-214X
- Publication type
Journal Article
- DOI
10.4274/turkderm.78300