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- Title
Evaluation of the whole auditory pathway using high-resolution and functional MRI at 7T parallel-transmit.
- Authors
Da Costa, Sandra; Clément, Jérémie; Gruetter, Rolf; Ipek, Özlem
- Abstract
Purpose: The aim of the present study is to show a MR procedure for the evaluation of simultaneous left and right auditory functions with functional MRI, and high-resolution acquisition of anatomical auditory pathway using parallel-transmit (pTx) methods at 7T. Methods: The time-efficient MR acquisition included two steps: RF weights were optimized for the regions-of-interest and high-resolution MR images of the inner-ear were acquired for the first 30 min (400 μm-iso resolution) followed by functional MRI acquisitions along the whole auditory pathway during the next 20 minutes. Data was processed with a linear cross-correlation analysis to define frequency preferences for each voxel in the auditory relays. Results: Tonotopic maps revealed ordered bilateral frequency gradients in the auditory relays whereas at the level of the cochlear nuclei and superior olivary complexes the frequency gradients were less evident. A 21% increase in transmit-field efficiency was achieved over the left/right inner-ear regions and thus its main structures were clearly discernible using the pTx methods, compared to a single transmit RF coil. Conclusion: Using 7T pTx allows a fast (less than 60 min in total) and qualitative evaluation of the simultaneous left and right auditory response along the entire auditory pathway, together with high-resolution anatomical images of the inner-ear. This could be further used for patient examination at 7T.
- Subjects
AUDITORY pathways; FUNCTIONAL magnetic resonance imaging; MAGNETIC resonance imaging; COCHLEAR nucleus; INNER ear; LINEAR statistical models; CONTRAST-enhanced magnetic resonance imaging
- Publication
PLoS ONE, 2021, Vol 16, Issue 9, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0254378