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- Title
Time to death in recurrence following curative resection of advanced gastric carcinoma.
- Authors
Lin Da-peng; Lu Ping; Liu Cai-gang; Xu Hui-mian; Wang Shu-bao; Chen Jun-qing
- Abstract
Objective The purpose of this study was to determine the factors that are predictive of early and late recurrences after gastrectomy. Methods The study included 158 patients who died of recurrent gastric carcinoma after curative gastrectomy that was performed in the Department of Oncology, First Affiliated Hospital of China Medical University, between 1990 -2000. Clinicopathologic findings were compared between 105 patients who died within 3 years after gastrectomy (early recurrence group) and 53 patients who died > 3 years after gastrectomy (late recurrence group). Multivariate analysis was performed to determine the independent factors correlated with the timing of recurrence. Results When compared with the late recurrence group, the early recurrence group was characterized by age at diagnosis ⩽60 years (57.1% in the early recurrence group vs. 28.3% in the late recurrence group), deep of invasion (SE/SI) (50.5 % vs. 28.3%), and positive lymph node metastasis (85.7 % vs. 67.9%). In multivariate analysis, the early recurrence group, was characterized by old ⩽60 years ( P = 0.001 ), positive depth of invasion ( P = 0. 024 ). Overall survival was influenced by age at diagnosis ( ⩽ 60 versus > 60 ; P = 0. 006 ), histological type ( well versus poor ; P = 0. 004 ), depth of in0vation ( MP/ SS versus SE/SI ; P = 0.003 ) , and lymph node metastasis ( positive versus negative ; P = 0.001 ). On multivariate analysis, survival time was found to be associated independently with the gender, age at diagnosis, depth of invasion, and lymph node metastasis (P < 0.05 ). Conclusions Lymph node metastasis and the age at diagnosis were the important factor predictive for early versus late recurrence. Patients who age at diagnosis ⩽ 60 years old with lymph node metastasis were at more risk of death within 3 years after curative operation for gastric cancer. Postoperative chemoradiotherapy should be especially recommended for patients at high risk of recurrence.
- Subjects
CHINA; STOMACH cancer; STOMACH surgery; GASTRECTOMY complications; CANCER chemotherapy; CANCER diagnosis; LYMPH nodes; CANCER invasiveness; MULTIVARIATE analysis; MEDICAL research
- Publication
Journal of Chinese Clinical Medicine, 2009, Vol 4, Issue 10, p565
- ISSN
1562-9023
- Publication type
Article