We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Work of Breathing in Premature Neonates: Noninvasive Neurally-Adjusted Ventilatory Assist versus Noninvasive Ventilation.
- Authors
Matlock, David N.; Bai, Shasha; Weisner, Michael D.; Comtois, Norman; Beck, Jennifer; Sinderby, Christer; Courtney, Sherry E.
- Abstract
BACKGROUND: We tested whether work of breathing in premature newborns estimated by phase angle (h) by using respiratory inductance plethysmography is decreased during neurally-adjusted ventilatory assist (NAVA) noninvasive ventilation (NIV) versus NIV alone. METHODS: NAVA NIV and NIV were applied in random order while using respiratory inductance plethysmography to measure the phase angle. RESULTS: Patient-ventilator asynchrony was decreased during NAVA NIV; however, the phase angle was not different between the modes. A large number of repeated assists with switches to backup were found when using NAVA NIV. Results of the analysis indicated these were due to the apnea alarm limit set during NAVA NIV. CONCLUSIONS: The improvement in patient-ventilator synchrony supports the hypothesis that work of breathing may be decreased with NAVA NIV; however, we were unable to demonstrate this with our study design. Short apnea time settings with NAVA NIV led to a large number of switches to backup and repeated assists during the same neural effort. (ClinicalTrials.gov registration NCT02788110.)
- Subjects
APNEA; ARTIFICIAL respiration; CLINICAL trials; PLETHYSMOGRAPHY; RESPIRATION; RESPIRATORY distress syndrome; RESPIRATORY insufficiency; RESPIRATORY muscles; STATISTICS; T-test (Statistics); MECHANICAL ventilators; DATA analysis; CONTINUING education units; DATA analysis software; POSITIVE end-expiratory pressure; CHILDREN
- Publication
Respiratory Care, 2020, Vol 65, Issue 7, p946
- ISSN
0020-1324
- Publication type
Article
- DOI
10.4187/respcare.07257