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- Title
Comparing Interventions for Management of Hot Flashes in Patients With Breast and Prostate Cancer: A Systematic Review With Meta-Analyses.
- Authors
Hutton, Brian; Hersi, Mona; Wei Cheng; Pratt, Misty; Barbeau, Pauline; Mazzarello, Sasha; Ahmadzai, Nadera; Skidmore, Becky; Morgan, Scott C.; Bordeleau, Louise; Ginex, Pamela K.; Sadeghirad, Behnam; Morgan, Rebecca L.; Cole, Katherine Marie; Clemons, Mark
- Abstract
PROBLEM IDENTIFICATION: Hot flashes are common and bothersome in patients with breast and prostate cancer and can adversely affect patients' quality of life. LITERATURE SEARCH: Databases were searched for randomized controlled trials (RCTs) evaluating the effects of one or more interventions for hot flashes in patients with a history of breast or prostate cancer. DATA EVALUATION: Outcomes of interest included changes in hot flash severity, hot flash frequency, quality of life, and harms. Pairwise meta-analyses and network meta-analyses were performed where feasible, with narrative synthesis used where required. SYNTHESIS: 40 RCTs were included. Findings from network meta-analysis for hot flash frequency suggested that several therapies may offer benefits compared to no treatment, but little data suggested differences between active therapies. Findings from network meta-analysis for hot flash score were similar. IMPLICATIONS FOR RESEARCH: Although many interventions may offer improvements for hot flashes versus no treatment, minimal data suggest important differences between therapies.
- Subjects
HOT flashes treatment; ANTINEOPLASTIC agents; BREAST tumors; CANCER patients; INFORMATION storage &; retrieval systems; MEDICAL databases; MEDICAL information storage &; retrieval systems; PSYCHOLOGY information storage &; retrieval systems; MEDLINE; META-analysis; PROSTATE tumors; QUALITY of life; RESEARCH funding; SYSTEMATIC reviews; DATA analysis software; DESCRIPTIVE statistics; AMED (Information retrieval system)
- Publication
Oncology Nursing Forum, 2020, Vol 47, Issue 4, pE86
- ISSN
0190-535X
- Publication type
Article
- DOI
10.1188/20.ONF.E86-E106