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- Title
Cytoophidia and filaments: you must unlearn what you have learned.
- Authors
Chen-Jun Guo; Ji-Long Liu
- Abstract
The nucleotide CTP can be synthesized de novo from UTP via the metabolic enzyme CTP synthase (CTPS). As a textbook enzyme, CTPS has been extensively studied for seven decades. However, it came as a surprise when CTPS was found to form snakeshaped mesoscale cytoophidia in fruit fly cells. Since 2010, more and more studies have demonstrated that CTPS can form cytoophidia within the cells across all three domains of life. Oligomers of CTPS form filaments that are undetectable under light microscopy. This review summarizes our current understanding of cytoophidia and filaments, high-lighting some basic features such as conservation, morphology and functions of the two levels of CTPS structures.
- Subjects
FIBERS; FRUIT flies; MICROSCOPY; OLIGOMERS
- Publication
Biochemical Society Transactions, 2023, Vol 51, Issue 3, p1245
- ISSN
0300-5127
- Publication type
Article
- DOI
10.1042/BST20221410