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- Title
The effect of heterogeneity in measles vaccination on population immunity.
- Authors
Glass K; Kappey J; Grenfell BT; Glass, K; Kappey, K; Grenfell, B T
- Abstract
High overall vaccination levels sometimes hide pockets of poor coverage. We adopted a meta-population framework to model local aggregation of populations, and used this to investigate the effects of vaccination heterogeneity. A recent survey of antibody levels in a community with low vaccination levels in The Netherlands enabled us to assess the relative importance of local and long-range infective contacts, and thus identify feasible levels of aggregation in the meta-population model. In the aggregated model, we found that heterogeneity in vaccination coverage can lead to a much increased rate of infection among unvaccinated individuals, with a simultaneous drop in the average age at infection.
- Publication
Epidemiology & Infection, 2004, Vol 132, Issue 4, p675
- ISSN
0950-2688
- Publication type
journal article
- DOI
10.1017/s0950268804002080