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- Title
Chlorpropamide Hepatotoxicity: Report of a Case and Review of the Literature.
- Authors
Schneider, H. L.; Hornbach, K. D.; Kniaz, J. L.; Efrusy, M. E.
- Abstract
Chlorpropamide, a sulfonylurea compound used in the treatment of diabetes mellitus, type II, has been implicated as the cause of untoward reactions involving the hematologist, cutaneous, and gastrointestinal systems. The hepatotoxic reactions induced by this drug generally present as hepatocanalicular cholestatic reactions, in contrast to the hepatocellular reactions induced by the older sulfonylurea compounds. An unusual presentation of chlorpropamide toxicity, presenting as a mixed hepatocanalicular reaction, is reported, along with a review of the literature.
- Subjects
CHLORPROPAMIDE; TYPE 2 diabetes; HYPOGLYCEMIC sulfonylureas; GASTROINTESTINAL system; DIABETES
- Publication
American Journal of Gastroenterology (Springer Nature), 1984, Vol 79, Issue 9, p721
- ISSN
0002-9270
- Publication type
Article