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- Title
Receptor recognition by gp130 cytokines.
- Authors
Bravo, Jer&oaacute;nimo; Heath, John K.
- Abstract
Cytokines of the gpl30 family exert their diverse biological effects by formation of stable high affinity transmembrane receptor complexes that are characterized by the presence of the shared transmembrane signalling receptor gpl30. Different gpl30 ligands form signalling complexes that vary in both composition and stoichiometry. Analysis of the three-dimensional structure of selected ligands and receptor dements indicates that ligands display three topologically conserved receptor recognition epitopes that interact with complementary ligand recognition dements. The composition of the signalling complex and downstream biological responses is defined by the relative affinity of different receptor components for these epitopes. The detailed structure of receptor recognition epitopes indicates that the generation of small molecule cytokine mimetics may be a feasible objective.
- Subjects
CYTOKINES; CELL receptors; EPITOPES; CELLULAR signal transduction; LIGANDS (Biochemistry); PHYSIOLOGICAL control systems
- Publication
EMBO Journal, 2000, Vol 19, Issue 11, p2399
- ISSN
0261-4189
- Publication type
Article
- DOI
10.1093/emboj/19.11.2399