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- Title
A Multivariate Analytic Approach to the Differential Diagnosis of Apraxia of Speech.
- Authors
Basilakos, Alexandra; Yourganov, Grigori; den Ouden, Dirk-Bart; Fogerty, Daniel; Rorden, Chris; Feenaughty, Lynda; Fridriksson, Julius
- Abstract
Purpose: Apraxia of speech (AOS) is a consequence of stroke that frequently co-occurs with aphasia. Its study is limited by difficulties with its perceptual evaluation and dissociation from co-occurring impairments. This study examined the classification accuracy of several acoustic measures for the differential diagnosis of AOS in a sample of stroke survivors. Method: Fifty-seven individuals were included (mean age = 60.8 ± 10.4 years; 21 women, 36 men; mean months poststroke = 54.7 ± 46). Participants were grouped on the basis of speech/language testing as follows: AOS-Aphasia (n = 20), Aphasia Only (n = 24), and Stroke Control (n = 13). Normalized Pairwise Variability Index, proportion of distortion errors, voice onset time variability, and amplitude envelope modulation spectrum variables were obtained from connected speech samples. Measures were analyzed for group differences and entered into a linear discriminant analysis to predict diagnostic classification. Results: Out-of-sample classification accuracy of all measures was over 90%. The envelope modulation spectrum variables had the greatest impact on classification when all measures were analyzed together. Conclusions: This study contributes to efforts to identify objective acoustic measures that can facilitate the differential diagnosis of AOS. Results suggest that further study of these measures is warranted to determine the best predictors of AOS diagnosis.
- Subjects
SOUTH Carolina; DIAGNOSIS of aphasia; DIAGNOSIS methods; ACOUSTIC measurements; SPEECH disorder diagnosis; ANALYSIS of variance; SPEECH evaluation; APHASIA; CHI-squared test; STATISTICAL correlation; DIFFERENTIAL diagnosis; DISCRIMINANT analysis; MULTIVARIATE analysis; PROBABILITY theory; QUESTIONNAIRES; RELIABILITY (Personality trait); RESEARCH evaluation; RESEARCH funding; STATISTICS; STROKE; T-test (Statistics); VIDEO recording; DATA analysis; RETROSPECTIVE studies; SEVERITY of illness index; DATA analysis software; SPEECH apraxia; DESCRIPTIVE statistics; KRUSKAL-Wallis Test; INTRACLASS correlation; DISEASE complications; DIAGNOSIS
- Publication
Journal of Speech, Language & Hearing Research, 2017, Vol 60, Issue 12, p3378
- ISSN
1092-4388
- Publication type
Article
- DOI
10.1044/2017_JSLHR-S-16-0443