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- Title
Retinal Arteriolar Narrowing Predicts Incidence of Diabetes.
- Authors
Nguyen, Thanh T.; Jie Jin Wang; Islam, F. M. Amirul; Mitchell, Paul; Tapp, Robyn J.; Zimmet, Paul Z.; Simpson, Richard; Shaw, Jonathan; Wong, Tien Y.
- Abstract
OBJECTIVE--To examine the relationship of retinal vascular caliber to incident diabetes in a population-based cohort. RESEARCH DESIGN AND METHODS--The Australian Diabetes, Obesity and Lifestyle (AusDiab) Study recruited adults aged 25+ years across Australia in 1999-2000, with a follow-up 5 years later in 2004-2005. Participants' glycemic status was classified using fasting plasma glucose (FPG) and 2-h oral glucose tolerance (2-h plasma glucose [2hPG]) tests. Diabetes was diagnosed if FPG was ge;7.0 mmol/l or 2hPG was ≥11.1 mmol/1. Retinal vascular caliber was measured from baseline retinal photographs using a computer-assisted program. RESULTS--Of the 803 participants without diabetes at baseline, 108 (13.4%) developed diabetes at follow-up: 7 (2.8%) of 246 participants with normal glucose tolerance, 9 (13.6%) of 66 participants with impaired fasting glucose, and 92 (18.7%) of 491 participants with impaired glucose tolerance. After multivariate analysis, participants with narrower retinal arteriolar caliber had a higher risk of diabetes (odds ratio 2.21 [95% CI 1.02-4.80], comparing smallest versus highest arteriolar caliber tertiles, P = 0.04 for trend). There was no association between retinal venular caliber and incident diabetes. CONCLUSIONS--Narrower retinal arteriolar caliber predicted risk of diabetes. These data provide further evidence that micro-vascular changes may contribute to the pathogenesis of diabetes. Diabetes 57:536-539, 2008
- Subjects
AUSTRALIA; DIABETES; GLUCOSE; MULTIVARIATE analysis; DIABETES risk factors
- Publication
Diabetes, 2008, Vol 57, Issue 3, p536
- ISSN
0012-1797
- Publication type
Article
- DOI
10.2337/db07-1376