We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
β-Cell Function Following Human Islet Transplantation for Type 1 Diabetes.
- Authors
Rickels, Michael R.; Schutta, Mark H.; Markmann, James F.; Barker, Clyde F.; Naji, Ali; Teff, Karen L.
- Abstract
Islet transplantation can provide metabolic stability for patients with type 1 diabetes; however, more than one donor pancreas is usually required to achieve insulin independence. To evaluate possible mechanistic defects underlying impaired graft function, we studied five subjects at 3 months and four subjects at 12 months following intraportal islet transplantation who had received comparable islet equivalents per kilogram (12,601 ± 1,732 vs. 14,384 ± 2,379, respectively). C-peptide responses, as measures of β-cell function, were significantly impaired in both transplant groups when compared with healthy control subjects(P < 0.05) after intravenous glucose(0.3 g/kg), an orally consumed meal (600 kcal), and intravenous arginine (5 g), with the greatest impairment to intravenous glucose and a greater impairment seen in the 12-month compared with the 3-month transplant group. A glucose-potentiated arginine test, performed only in insulin-independent transplant subjects (n = 5), demonstrated significant impairments in the glucose-potentiation slope(P < 0.05) and the maximal response to arginine(ARmax; P < 0.05), a measure of β-cell secretory capacity. Because ARmax provides an estimate of the functional β-cell mass, these results suggest that a low engrafted β-cell mass may account for the functional defects observed after islet transplantation. Diabetes 54:100-106, 2005
- Subjects
ISLANDS of Langerhans transplantation; TRANSPLANTATION of organs, tissues, etc.; DIABETES; PANCREATIC beta cells; C-peptide; ARGININE
- Publication
Diabetes, 2005, Vol 54, Issue 1, p100
- ISSN
0012-1797
- Publication type
Article
- DOI
10.2337/diabetes.54.1.100