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- Title
The Role of Gut Microbiota in the Clinical Outcome of Septic Patients: State of the Art and Future Perspectives.
- Authors
Marascio, Nadia; Scarlata, Giuseppe Guido Maria; Romeo, Francesco; Cicino, Claudia; Trecarichi, Enrico Maria; Quirino, Angela; Torti, Carlo; Matera, Giovanni; Russo, Alessandro
- Abstract
Sepsis is a life-threatening multiple-organ dysfunction caused by a dysregulated host response to infection, with high mortality worldwide; 11 million deaths per year are attributable to sepsis in high-income countries. Several research groups have reported that septic patients display a dysbiotic gut microbiota, often related to high mortality. Based on current knowledge, in this narrative review, we revised original articles, clinical trials, and pilot studies to evaluate the beneficial effect of gut microbiota manipulation in clinical practice, starting from an early diagnosis of sepsis and an in-depth analysis of gut microbiota.
- Subjects
GUT microbiome; HIGH-income countries; SEPSIS; PILOT projects; RESEARCH teams
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 11, p9307
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms24119307