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- Title
Endothelin-1 as a Biomarker of Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Associated with Autoimmune Diseases.
- Authors
Pulito-Cueto, Verónica; Genre, Fernanda; López-Mejías, Raquel; Mora-Cuesta, Víctor Manuel; Iturbe-Fernández, David; Portilla, Virginia; Sebastián Mora-Gil, María; Ocejo-Vinyals, Javier Gonzalo; Gualillo, Oreste; Blanco, Ricardo; Corrales, Alfonso; Ferraz-Amaro, Iván; Castañeda, Santos; Cifrián Martínez, José Manuel; Atienza-Mateo, Belén; Remuzgo-Martínez, Sara; González-Gay, Miguel Ángel
- Abstract
The aim of this study was to determine the role of endothelin-1 (ET-1), a molecule involved in multiple vascular and fibrosing abnormalities, as a biomarker of interstitial lung disease (ILD), as well as its use for the differential diagnosis between idiopathic pulmonary fibrosis (IPF) and ILD associated with autoimmune diseases (AD-ILD), using a large and well-defined cohort of patients with ILD. A total of 112 patients with IPF, 91 patients with AD-ILD (28 rheumatoid arthritis (RA), 26 systemic sclerosis, 20 idiopathic inflammatory myositis and 17 interstitial pneumonia with autoimmune features) and 44 healthy controls were included. ET-1 serum levels were determined by enzyme-linked immunosorbent assay. A significant increase in ET-1 levels was found in patients with IPF compared to controls. Likewise, AD-ILD patients also showed higher ET-1 levels than controls when the whole cohort was stratified by the type of AD. Similar ET-1 levels were found in IPF and AD-ILD patients, regardless of the underlying AD. Interestingly, increased ET-1 levels were correlated with worse lung function in IPF and RA-ILD patients. Our study supports that serum ET-1 may be useful as a biomarker of ILD, although it could not help in the differential diagnosis between IPF and AD-ILD. Moreover, ET-1 levels may be associated with ILD severity.
- Subjects
PULMONARY fibrosis; IDIOPATHIC pulmonary fibrosis; INTERSTITIAL lung diseases; AUTOIMMUNE diseases; MYOSITIS; LUNGS; PREPROENDOTHELIN
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 2, p1275
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms24021275