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- Title
Platinum(II) O,S Complexes Inhibit the Aggregation of Amyloid Model Systems.
- Authors
Florio, Daniele; Malfitano, Anna Maria; Di Somma, Sarah; Mügge, Carolin; Weigand, Wolfgang; Ferraro, Giarita; Iacobucci, Ilaria; Monti, Maria; Morelli, Giancarlo; Merlino, Antonello; Marasco, Daniela
- Abstract
Platinum(II) complexes with different cinnamic acid derivatives as ligands were investigated for their ability to inhibit the aggregation process of amyloid systems derived from Aβ, Yeast Prion Protein Sup35p and the C-terminal domain of nucleophosmin 1. Thioflavin T binding assays and circular dichroism data indicate that these compounds strongly inhibit the aggregation of investigated peptides exhibiting IC50 values in the micromolar range. MS analysis confirms the formation of adducts between peptides and Pt(II) complexes that are also able to reduce amyloid cytotoxicity in human SH-SY5Y neuroblastoma cells. Overall data suggests that bidentate ligands based on β-hydroxy dithiocinnamic esters can be used to develop platinum or platinoid compounds with anti-amyloid aggregation properties.
- Subjects
ACID derivatives; CINNAMIC acid; CLUSTERING of particles; AMYLOID; PLATINUM; PLATINUM group; NUCLEOPHOSMIN
- Publication
International Journal of Molecular Sciences, 2019, Vol 20, Issue 4, p829
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms20040829