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- Title
Friedel–Crafts Alkylation of N-(2-Chloropropionyl)aniline and the Generation Mechanism of Byproducts.
- Authors
Tian, Jun; Li, Lei; Yan, Xilong; Chen, Ligong
- Abstract
The of N-(2-chloropropionyl)aniline to 3-methylindolin-2-one through was studied. It was found that N-phenylacrylamide (12.6%) and 3,4-dihydro-2(1 H)-quinolinone (1.5%) as main byproducts were obtained. On the basis of the mechanism of , the generation mechanisms of these two compounds were proposed.
- Subjects
ANILINE; FRIEDEL-Crafts reaction; ALKYLATION; QUINOLONE antibacterial agents; ACRYLAMIDE
- Publication
Journal of Heterocyclic Chemistry, 2014, Vol 51, Issue 6, p1811
- ISSN
0022-152X
- Publication type
Article
- DOI
10.1002/jhet.1895