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- Title
Improved.
- Authors
Usuki, Toyonobu; Yanuma, Hiroto; Hayashi, Takahiro; Yamada, Haruka; Suzuki, Noriyuki; Masuyama, Yoshiro
- Abstract
The Negishi of an organozinc derivative prepared from protected l-aspartic acid with monohalopyridines was improved by employing a combination catalyst of Pd2(dba)3 and P(2-furyl)3 and removing an extra Zn from the organozinc reagent via centrifugation. The reactivity of halogenated pyridines (Cl, Br, I) with substituents at the C2, C3, and C4 positions of the pyridine ring was investigated, and it was found that the use of 4-iodopyridine as a substrate gave the best yield (90%) for the .
- Subjects
PYRIDINE synthesis; ORGANOZINC compounds; ASPARTIC acid; PALLADIUM catalysts; COUPLING reactions (Chemistry); CENTRIFUGATION
- Publication
Journal of Heterocyclic Chemistry, 2014, Vol 51, Issue 1, p269
- ISSN
0022-152X
- Publication type
Article
- DOI
10.1002/jhet.1807