We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Mid-Thigh Cortical Bone Structural Parameters, Muscle Mass and Strength, and Association with Lower Limb Fractures in Older Men and Women (AGES-Reykjavik Study).
- Authors
Johannesdottir, Fjola; Aspelund, Thor; Siggeirsdottir, Kristin; Jonsson, Brynjolfur; Mogensen, Brynjolfur; Sigurdsson, Sigurdur; Harris, Tamara; Gudnason, Vilmundur; Lang, Thomas; Sigurdsson, Gunnar
- Abstract
In a cross-sectional study we investigated the relationship between muscle and bone parameters in the mid-thigh in older people using data from a single axial computed tomographic section through the mid-thigh. Additionally, we studied the association of these variables with incident low-trauma lower limb fractures. A total of 3,762 older individuals (1,838 men and 1,924 women), aged 66-96 years, participants in the AGES-Reykjavik study, were studied. The total cross-sectional muscular area and knee extensor strength declined with age similarly in both sexes. Muscle parameters correlated most strongly with cortical area and total shaft area (adjusted for age, height, and weight) but explained <10 % of variability in those bone parameters. The increment in medullary area (MA) and buckling ratio (BR) with age was almost fourfold greater in women than men. The association between MA and muscle parameters was nonsignificant. During a median follow-up of 5.3 years, 113 women and 66 men sustained incident lower limb fractures. Small muscular area, low knee extensor strength, large MA, low cortical thickness, and high BR were significantly associated with fractures in both sexes. Our results show that bone and muscle loss proceed at different rates and with different gender patterns.
- Subjects
MUSCLE strength; LEG injuries; BONE fractures; DISEASES in older people; TOMOGRAPHY; CROSS-sectional method; RISK factors of fractures
- Publication
Calcified Tissue International, 2012, Vol 90, Issue 5, p354
- ISSN
0171-967X
- Publication type
Article
- DOI
10.1007/s00223-012-9585-6