We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Le (−)-(2 S)-2-Hydroxyhexanedioate de diéthyle, nouveau bloc chiral pour la synthèse énantiospécifique.
- Authors
Blaser, Florian; Deschenaux, Pierre-François; Kallimopoulos, Thomas; Jacot-Guillarmod, André
- Abstract
The (−)-(2 S)-Diethyl 2-Hydroxyhexanedioate, a New Chiral Building Block for Enantioselective Synthesis (−)-(2 S)-Diethyl 2-hydroxyhexanedioate ((2 S)-3) has been obtained by enantioselective reduction of diethyl 2-oxohexanedioate ( 1) with baker's yeast. The key intermediate (−)-(5 S)-ethyl 5,6-dihydroxyhexanoate ((5 S)- 5) is proved to be a useful synthon for the synthesis of chiral δ-lactones and a precursor of leukotriene LTB4 ((5 S)- 13).
- Publication
Helvetica Chimica Acta, 1991, Vol 74, Issue 1, p141
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.19910740116