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- Title
Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas: "it's a numbers game"—implications for WNT medulloblastoma dose-reduction clinical trials.
- Authors
Gottardo, Nicholas G.
- Abstract
Goschzik and colleagues [[3]] identified I TP53 i mutation and I OTX2 i gain as independent prognostic markers in WNT medulloblastoma patients. In COG ACNS0331, only 3% (1/37) of the 64 WNT patients had a I TP53 i mutation and 5-year EFS was 93.3%, with only 4 local failures [[5]], while in ACNS0332, 11% (1/9) had a I TP53 i mutation and only one patient relapsed (Tables 1 and 2) [[4]]. Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas: "it's a numbers game" - implications for WNT medulloblastoma dose-reduction clinical trials.
- Subjects
MEDULLOBLASTOMA; RECREATIONAL mathematics; CLINICAL trials; ALEMTUZUMAB; GENE expression profiling
- Publication
Acta Neuropathologica, 2023, Vol 145, Issue 1, p145
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/s00401-022-02518-0