Found: 59
Select item for more details and to access through your institution.
LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson's disease.
- Published in:
- NPJ Parkinson's Disease, 2022, v. 8, n. 1, p. 1, doi. 10.1038/s41531-022-00354-3
- By:
- Publication type:
- Article
PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.
- Published in:
- Frontiers in Molecular Neuroscience, 2017, p. 1, doi. 10.3389/fnmol.2017.00417
- By:
- Publication type:
- Article
LRRK2 G2019S kinase activity triggers neurotoxic NSF aggregation.
- Published in:
- 2021
- By:
- Publication type:
- journal article
Kinase activity of mutant LRRK2 manifests differently in hetero-dimeric vs. homo-dimeric complexes.
- Published in:
- Biochemical Journal, 2019, v. 476, n. 3, p. 559, doi. 10.1042/BCJ20180589
- By:
- Publication type:
- Article
The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP+ Treatment by Altering LRRK2 Binding to DRP1.
- Published in:
- Frontiers in Molecular Neuroscience, 2018, p. 1, doi. 10.3389/fnmol.2018.00064
- By:
- Publication type:
- Article
P3-423: LRRK2 regulates the stress response in C. elegans and mammalian cells
- Published in:
- 2008
- By:
- Publication type:
- Abstract
Age-dependent dopamine transporter dysfunction and Serine129 phospho-α- synuclein overload in G2019S LRRK2 mice.
- Published in:
- Acta Neuropathologica Communications, 2017, v. 5, p. 1, doi. 10.1186/s40478-017-0426-8
- By:
- Publication type:
- Article
Analysis of the Catecholaminergic Phenotype in Human SH-SY5Y and BE(2)-M17 Neuroblastoma Cell Lines upon Differentiation.
- Published in:
- PLoS ONE, 2015, v. 10, n. 8, p. 1, doi. 10.1371/journal.pone.0136769
- By:
- Publication type:
- Article
α-Synuclein Oligomers Induced by Docosahexaenoic Acid Affect Membrane Integrity.
- Published in:
- PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0082732
- By:
- Publication type:
- Article
Biochemical Characterization of Highly Purified Leucine-Rich Repeat Kinases 1 and 2 Demonstrates Formation of Homodimers.
- Published in:
- PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0043472
- By:
- Publication type:
- Article
The Parkinson's Disease Associated LRRK2 Exhibits Weaker In Vitro Phosphorylation of 4E-BP Compared to Autophosphorylation.
- Published in:
- PLoS ONE, 2010, v. 5, n. 1, p. 1, doi. 10.1371/journal.pone.0008730
- By:
- Publication type:
- Article
Too much for your own good: Excessive dopamine damages neurons and contributes to Parkinson's disease: An Editorial Highlight for " Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo "
- Published in:
- Journal of Neurochemistry, 2021, v. 158, n. 4, p. 833, doi. 10.1111/jnc.15442
- By:
- Publication type:
- Article
Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD.
- Published in:
- BMC Neurology, 2006, v. 6, p. 1, doi. 10.1186/1471-2377-6-44
- By:
- Publication type:
- Article
The Chaperone Activity of Heat Shock Protein 90 Is Critical for Maintaining the Stability of Leucine-Rich Repeat Kinase 2.
- Published in:
- Journal of Neuroscience, 2008, v. 28, n. 13, p. 3384, doi. 10.1523/JNEUROSCI.0185-08.2008
- By:
- Publication type:
- Article
Alpha-synuclein overexpression increases dopamine toxicity in BE2-M17 cells.
- Published in:
- 2010
- By:
- Publication type:
- journal article
α-Synuclein overexpression increases dopamine toxicity in BE(2)-M17 cells.
- Published in:
- BMC Neuroscience, 2010, v. 11, p. 41, doi. 10.1186/1471-2202-11-41
- By:
- Publication type:
- Article
Levetiracetam treatment ameliorates LRRK2 pathological mutant phenotype.
- Published in:
- Journal of Cellular & Molecular Medicine, 2019, v. 23, n. 12, p. 8505, doi. 10.1111/jcmm.14674
- By:
- Publication type:
- Article
Dysfunction of dopamine homeostasis: clues in the hunt for novel Parkinson's disease therapies.
- Published in:
- FASEB Journal, 2013, v. 27, n. 6, p. 2101, doi. 10.1096/fj.12-226852
- By:
- Publication type:
- Article
GTP binding controls complex formation by the human ROCO protein MASL1.
- Published in:
- FEBS Journal, 2014, v. 281, n. 1, p. 261, doi. 10.1111/febs.12593
- By:
- Publication type:
- Article
DOPAL initiates αSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinson's disease.
- Published in:
- NPJ Parkinson's Disease, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41531-023-00485-1
- By:
- Publication type:
- Article
Evaluation of UVC Excimer Lamp (222 nm) Efficacy for Coronavirus Inactivation in an Animal Model.
- Published in:
- Viruses (1999-4915), 2022, v. 14, n. 9, p. 2038, doi. 10.3390/v14092038
- By:
- Publication type:
- Article
Leucine‐rich repeat kinase 2 and lysosomal dyshomeostasis in Parkinson disease.
- Published in:
- Journal of Neurochemistry, 2020, v. 152, n. 3, p. 273, doi. 10.1111/jnc.14908
- By:
- Publication type:
- Article
Leucine‐rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre‐synaptic sites.
- Published in:
- Journal of Neurochemistry, 2019, v. 150, n. 3, p. 264, doi. 10.1111/jnc.14778
- By:
- Publication type:
- Article
Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.
- Published in:
- Journal of Neurochemistry, 2015, v. 135, n. 6, p. 1242, doi. 10.1111/jnc.13369
- By:
- Publication type:
- Article
Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.
- Published in:
- Journal of Neurochemistry, 2014, v. 131, n. 2, p. 239, doi. 10.1111/jnc.12798
- By:
- Publication type:
- Article
Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant.
- Published in:
- Journal of Neurochemistry, 2011, v. 116, n. 2, p. 304, doi. 10.1111/j.1471-4159.2010.07105.x
- By:
- Publication type:
- Article
MKK6 binds and regulates expression of Parkinson’s disease-related protein LRRK2.
- Published in:
- Journal of Neurochemistry, 2010, v. 112, n. 6, p. 1593, doi. 10.1111/j.1471-4159.2010.06568.x
- By:
- Publication type:
- Article
Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4.
- Published in:
- 2018
- By:
- Publication type:
- journal article
GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.
- Published in:
- Human Molecular Genetics, 2017, v. 26, n. 14, p. 2747, doi. 10.1093/hmg/ddx161
- By:
- Publication type:
- Article
The chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing α-synuclein cellular toxicity.
- Published in:
- Human Molecular Genetics, 2014, v. 23, n. 21, p. 5615, doi. 10.1093/hmg/ddu275
- By:
- Publication type:
- Article
GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2.
- Published in:
- Human Molecular Genetics, 2013, v. 22, n. 6, p. 1140, doi. 10.1093/hmg/dds522
- By:
- Publication type:
- Article
Sequestosome-1 (SQSTM1/p62) as a target in dopamine catabolite-mediated cellular dyshomeostasis.
- Published in:
- Cell Death & Disease, 2024, v. 15, n. 6, p. 1, doi. 10.1038/s41419-024-06763-x
- By:
- Publication type:
- Article
Human frataxin, the Friedreich ataxia deficient protein, interacts with mitochondrial respiratory chain.
- Published in:
- Cell Death & Disease, 2023, v. 14, n. 12, p. 1, doi. 10.1038/s41419-023-06320-y
- By:
- Publication type:
- Article
LRRK2 signaling in neurodegeneration: two decades of progress.
- Published in:
- Essays in Biochemistry, 2021, v. 65, n. 7, p. 859, doi. 10.1042/EBC20210013
- By:
- Publication type:
- Article
The role of LRRK2 in cytoskeletal dynamics.
- Published in:
- Biochemical Society Transactions, 2018, v. 46, n. 6, p. 1653, doi. 10.1042/BST20180469
- By:
- Publication type:
- Article
Cross-talk between LRRK2 and PKA: implication for Parkinson's disease?
- Published in:
- Biochemical Society Transactions, 2017, v. 45, n. 1, p. 261, doi. 10.1042/BST20160396
- By:
- Publication type:
- Article
Presynaptic dysfunction in Parkinson's disease: a focus on LRRK2.
- Published in:
- Biochemical Society Transactions, 2012, v. 40, n. 5, p. 1111, doi. 10.1042/BST20120124
- By:
- Publication type:
- Article
Role of LRRK2 kinase activity in the pathogenesis of Parkinson's disease.
- Published in:
- Biochemical Society Transactions, 2012, v. 40, n. 5, p. 1058, doi. 10.1042/BST20120054
- By:
- Publication type:
- Article
Biophysical groundwork as a hinge to unravel the biology of α-synuclein aggregation and toxicity.
- Published in:
- Quarterly Reviews of Biophysics, 2014, v. 47, n. 1, p. 1, doi. 10.1017/S0033583513000097
- By:
- Publication type:
- Article
Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson's disease.
- Published in:
- Acta Neuropathologica, 2022, v. 144, n. 1, p. 81, doi. 10.1007/s00401-022-02437-0
- By:
- Publication type:
- Article
A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively.
- Published in:
- Cells (2073-4409), 2022, v. 11, n. 6, p. 1018, doi. 10.3390/cells11061018
- By:
- Publication type:
- Article
Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues.
- Published in:
- Cells (2073-4409), 2020, v. 9, n. 11, p. 2344, doi. 10.3390/cells9112344
- By:
- Publication type:
- Article
Ceramides in Parkinson's Disease: From Recent Evidence to New Hypotheses.
- Published in:
- Frontiers in Neuroscience, 2019, p. N.PAG, doi. 10.3389/fnins.2019.00330
- By:
- Publication type:
- Article
LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate.
- Published in:
- Molecular Neurodegeneration, 2016, v. 11, p. 1, doi. 10.1186/s13024-015-0066-z
- By:
- Publication type:
- Article
Leucine-rich repeat kinase 2 and alpha-synuclein: intersecting pathways in the pathogenesis of Parkinson's disease?
- Published in:
- Molecular Neurodegeneration, 2011, v. 6, n. 1, p. 6, doi. 10.1186/1750-1326-6-6
- By:
- Publication type:
- Article
Erratum to: Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells.
- Published in:
- 2016
- By:
- Publication type:
- corrected article
Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells.
- Published in:
- 2015
- By:
- Publication type:
- journal article
LRRK2 and neuroinflammation: partners in crime in Parkinson's disease?
- Published in:
- Journal of Neuroinflammation, 2014, v. 11, n. 1, p. 1, doi. 10.1186/1742-2094-11-52
- By:
- Publication type:
- Article
LRRK2 and neuroinflammation: partners in crime in Parkinson's disease?
- Published in:
- 2014
- By:
- Publication type:
- journal article
Extracellular clusterin limits the uptake of α‐synuclein fibrils by murine and human astrocytes.
- Published in:
- Glia, 2021, v. 69, n. 3, p. 681, doi. 10.1002/glia.23920
- By:
- Publication type:
- Article