We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Worsening of Respiratory Status during Neutropenia Recovery in Noncritically Ill Hematological Patients: Results of a Prospective Multicenter Study.
- Authors
Balsat, Marie; Xhaard, alienor; Lengline, Etienne; Tavernier, Emmanuelle; Cornillon, Jérôme; Guyotat, Denis; Darmon, Michael
- Abstract
Background: Neutropenia recovery (NR) has been associated with worsening preexisting lung injury in up to 50% of critically ill cancer patients. However, only limited relevant data exist in the general population of hematological patients. Objectives: To assess the incidence of acute respiratory deterioration during NR in patients with hematological malignancies. Methods: Adult patients with neutropenia expected to last more than 7 days were included. Worsening of respiratory status (WRS) was defined as a decrease in oxygen saturation of ≥5%, the need for oxygen therapy for ≥24 h, an increase in oxygen flow of ≥50% in patients previously treated with oxygen, or the need for mechanical ventilation. NR was defined as the 3 days preceding or following a neutrophil count of >0.5 × 109/l. Results: A total of 16 of 50 patients included in this pilot study experienced WRS during NR (32%), and 13 patients had WRS during neutropenia (26%). The incidence density of WRS was 0.53 (±0.79) episodes per 10 days during NR and 0.20 (±0.39) episodes per 10 days during neutropenia (p = 0.004). Sepsis, stem cell transplantation, preexisting pneumonia, or the use of granulocyte colony-stimulating factor were not associated with WRS during NR. Conclusion: Up to one third of noncritically ill hematological patients with expected neutropenia of more than 7 days experience WRS during NR. Clinical consequences and risk factors for WRS during NR remain to be evaluated. © 2015 S. Karger AG, Basel
- Subjects
NEUTROPENIA; CANCER patients; LONGITUDINAL method; MEDICAL cooperation; RESEARCH; DATA analysis software; DESCRIPTIVE statistics; HEMATOLOGIC malignancies; THERAPEUTICS
- Publication
Respiration, 2015, Vol 90, Issue 3, p229
- ISSN
0025-7931
- Publication type
Article
- DOI
10.1159/000433556