We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Pathogenesis of experimental aural cholesteatoma in the chinchilla.
- Authors
Imamura, Shun-ichi; Nozawa, Izuru; Imamura, Mayumi; Murakami, Yoshihiko; Imamura, S; Nozawa, I; Imamura, M; Murakami, Y
- Abstract
Histopathological observation of celloidin serial sections of the chinchilla middle ear after treatment with propylene glycol disclosed the development of severe inflammation of the middle ear mucosa and tympanic membrane, papillary proliferation of the epidermis of the tympanic membrane and external auditory meatus, and retraction and adhesion of the tympanic membrane. The findings for the tympanic membrane, impedance testing and histopathological examination suggested that there were two types of acquired cholesteatoma formation, probably with a difference in the pathogenesis. In one type, the proliferated epidermal layer of the tympanic membrane penetrated into the middle ear cavity making tympanic perforations. In the other type, there was progressive retraction of the tympanic membrane forming a retraction pocket. We discuss the two different patterns of cholesteatoma development.
- Publication
ORL, 1999, Vol 61, Issue 2, p84
- ISSN
0301-1569
- Publication type
journal article
- DOI
10.1159/000027647