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- Title
A Case of Pulmonary Lymphomatoid Granulomatosis Successfully Treated by Combination Chemotherapy with Rituximab.
- Authors
Ki Hwan Jung; Hwa Jung Sung; Ju-Han Lee; Ki Yeol Lee; Jae Seung Shin; Kyung Min Kim; Young-Sik Kim; Chol Shin; Je Hyeong Kim
- Abstract
Lymphomatoid granulomatosis (LYG) is a rare angiocentric and angiodestructive lymphoproliferative disease characterized by Epstein-Barr virus-positive B cells admixed with reactive T cells. LYG most commonly affects the lung but can also involve other extrapulmonary sites. Pulmonary LYG usually presents as multiple pulmonary nodules with rapid progression and excavation. It can mimic various infectious diseases, vasculitis or metastatic malignancy and is difficult to be diagnosed clinically. Standard treatment for LYG has not yet been established. Despite combination chemotherapy, the overall prognosis is poor. Recently, anti-CD20 monoclonal antibody, rituximab, has been used to treat LYG. We report the case of a 70-year-old male patient with pulmonary LYG, who showed rapid remission of the disease after combination chemotherapy with rituximab. Copyright © 2009 S. Karger AG, Basel
- Subjects
LYMPHOPROLIFERATIVE disorders; EPSTEIN-Barr virus; T cells; DRUG therapy; THERAPEUTIC use of immunoglobulins; OLDER men; RITUXIMAB; THERAPEUTICS; DISEASES in older people
- Publication
Chemotherapy (0009-3157), 2009, Vol 55, Issue 5, p386
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000237745