We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Cancer: Three birds with one stone.
- Authors
Toledo, Franck; Bardot, Boris
- Abstract
The article reports on the result of a study which examines the third function for p53's DNA-binding domain. The researchers discover that DNA-binding domain of p53 protein is required for its interaction with Drosha. It reveals that p53 probably binds to the p68 RNA-helicase component of the Drosha complex. It finds that the three types of missense mutation in the DNA-binding domain of p53 that obliterate its transcriptional activity also lead to decrease processing of primiRNAs by Drosha. Moreover, it cites that p53 mutants might lessen the interaction between pri-miRNAs and Drosha-complex proteins.
- Subjects
P53 protein; DNA-binding proteins; DNA helicases; RNA; PROTEINS; GENETIC mutation; MESSENGER RNA; TUMOR suppressor proteins; TRANSCRIPTION factors
- Publication
Nature, 2009, Vol 460, Issue 7254, p466
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/460466a