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- Title
The effect of 17-alpha-hydroxyprogesterone caproate on 75 g oral glucose tolerance test results and the prevalence of gestational diabetes mellitus.
- Authors
Madendag, Ilknur Col; Sahin, Mefkure Eraslan
- Abstract
Aim: The goal of the present study was to investigate the effects of 17-alpha-hydroxyprogesterone caproate (17-OHPC) on oral glucose tolerance test (75 g OGTT) results and the prevalence of gestational diabetes mellitus (GDM). Material and Methods:: In the present case-control study, 1,472 pregnant women were enrolled. Of these pregnant women, 146 had used 17-OHPC for at least one month between 16-24 weeks of gestation and the remaining 1,326 were the healthy control group. Diagnostic criteria presented by International Association of Diabetes and Pregnancy Study Group were applied for diagnosis GDM. Results: Maternal demographic characteristics were similar between groups. The mean starvation serum glucose level was importantly greater in the study group at 81.7 ± 9.3mg/dL versus 79.6 ± 13.3mg/dL in the control group. Mean first hour serum glucose was 144.4 ± 30.4mg/dl in the study group and 130.8 ± 36.9mg/dl in the control group, importantly greater in the study group. Mean second hour serum glucose was importantly greater in the study group at 111.5 ± 26.1mg/dl versus 104.8 ± 31.4mg/dl in the control group. Additionally, there was no statistically significant difference between the groups for GDM prevalence. Conclusion: The present study showed that 17-OHPC was importantly related to greater starvation, first hour, and second hour serum glucose levels compared with the healthy group.
- Subjects
GESTATIONAL diabetes; 17-hydroxyprogesterone; GLUCOSE tolerance tests; DISEASE prevalence; CONTROL groups
- Publication
Annals of Medical of Research, 2020, Vol 27, Issue 4, p1126
- ISSN
2636-7688
- Publication type
Article
- DOI
10.5455/annalsmedres.2019.12.843