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- Title
From glutamate co-release to vesicular synergy: vesicular glutamate transporters.
- Authors
El Mestikawy, Salah; Wallén-Mackenzie, Åsa; Fortin, Guillaume M.; Descarries, Laurent; Trudeau, Louis-Eric; Wallén-Mackenzie, Asa
- Abstract
Recent data indicate that 'classical' neurotransmitters can also act as co-transmitters. This notion has been strengthened by the demonstration that three vesicular glutamate transporters (vesicular glutamate transporter 1 (VGLUT1), VGLUT2 and VGLUT3) are present in central monoamine, acetylcholine and GABA neurons, as well as in primarily glutamatergic neurons. Thus, intriguing questions are raised about the morphological and functional organization of neuronal systems endowed with such a dual signalling capacity. In addition to glutamate co-release, vesicular synergy - a process leading to enhanced packaging of the 'primary' transmitter - is increasingly recognized as a major property of the glutamatergic co-phenotype. The behavioural relevance of this co-phenotype is presently the focus of considerable interest.
- Subjects
NEUROTRANSMITTERS; NEURAL transmission; NERVOUS system; NEURONS; PHENOTYPES
- Publication
Nature Reviews Neuroscience, 2011, Vol 12, Issue 4, p204
- ISSN
1471-003X
- Publication type
journal article
- DOI
10.1038/nrn2969