We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Association between tumor-infiltrating lymphocytes and survival in patients with metastatic breast cancer receiving first-line chemotherapy: analysis of CALGB 40502.
- Authors
Stover, Daniel G.; Salgado, Roberto; Savenkov, Oleksander; Ballman, Karla; Mayer, Erica L.; Magbanua, Mark Jesus M.; Loi, Sherene; Vater, Mark; Glover, Kristyn; Watson, Mark; Wen, Yujia; Symmans, W. Fraser; Perou, Charles; Carey, Lisa A.; Partridge, Ann H.; Rugo, Hope S.
- Abstract
Association of stromal tumor-infiltrating lymphocytes (sTILs) with survival outcomes among patients with metastatic breast cancer (MBC) remains unclear. The primary objective was to evaluate the association of sTILs with progression-free survival in randomized phase III trial CALGB 40502. sTILs were associated with progression-free and overall survival in chemotherapy-treated MBC when controlling for treatment arm; however, this effect did not remain significant after additional adjustment for hormone receptor status. CALGB is now part of the Alliance for Clinical Trials in Oncology. Trial Registration: ClinicalTrials.gov: NCT00785291.
- Subjects
METASTATIC breast cancer; TUMOR-infiltrating immune cells; OVERALL survival; CLINICAL trials; PROGRESSION-free survival; HORMONE receptor positive breast cancer
- Publication
NPJ Breast Cancer, 2024, Vol 10, Issue 1, p1
- ISSN
2374-4677
- Publication type
Article
- DOI
10.1038/s41523-024-00683-x