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- Title
Parallel profiling of antigenicity alteration and immune escape of SARS-CoV-2 Omicron and other variants.
- Authors
Sun, Cong; Kang, Yin-Feng; Liu, Yuan-Tao; Kong, Xiang-Wei; Xu, Hui-Qin; Xiong, Dan; Xie, Chu; Liu, Yi-Hao; Peng, Sui; Feng, Guo-Kai; Liu, Zheng; Zeng, Mu-Sheng
- Abstract
SARS-CoV-2 variants have evolved a variety of critical mutations, leading to antigenicity changes and immune escape. The recent emerging SARS-CoV-2 Omicron variant attracted global attention due to its significant resistance to current antibody therapies and vaccines. Here, we profiled the mutations of Omicron and other various circulating SARS-CoV-2 variants in parallel by computational interface analysis and in vitro experimental assays. We identified critical mutations that lead to antigenicity changes and diminished neutralization efficiency of a panel of 14 antibodies due to diverse molecular mechanisms influencing the antigen-antibody interaction. Our study identified that Omicron exhibited extraordinary potency in immune escape compared to the other variants of concern, and explores the application of computational interface analysis in SARS-CoV-2 mutation surveillance and demonstrates its potential for the early identification of concerning variants, providing preliminary guidance for neutralizing antibody therapy.
- Publication
Signal Transduction & Targeted Therapy, 2022, Vol 7, Issue 1, p1
- ISSN
2095-9907
- Publication type
Article
- DOI
10.1038/s41392-022-00910-6