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- Title
Polyunsaturated fatty acid in treatment resistant depression: A pilot study.
- Authors
Jannini, T.; Longo, L.; Barone, Y.; Niolu, C.; Bernardini, S.; Siracusano, A.; Bertucci, P.; Di Lorenzo, G.
- Abstract
Introduction: The deficiency of polyunsaturated fatty acids (PUFAs) and an alteration between the ratio of omega-6 and omega-3 PUFAs may contribute to the pathogenesis of depressive disorders. Objectives: To investigate the levels of omega-3 and omega-6 in red cell membranes (mPUFAs) and plasma (pPUFAs) of patients with treatment-resistant (TRD) and non-treatment resistant depression (non-TRD). Methods: TRDand non-TRDconsisted of 75 patients enrolled at the Psychiatric and Clinic Psychology Unit of the University of Rome Tor Vergata, Rome, Italy, and met the DSM-IV criteria for major depressive disorder (MDD). A group of healthy controls (HC) matched for agender and age was enrolled. All blood samples were performed in conditions of an empty stomach between 07:00 amand 09:00am. For each subjectwere obtained 5 ml ofwhole blood with the use of tubes for plasma with EDTA as an anticoagulant. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) for omega-3 and arachidonic acid (AA) for omega-6 were measured. Results: Levels of pPUFAs did not differ between the three groups. The mPUFAs were altered in the MDD. TRD and non-TRD had lower EPA and AA values respect to the HC. DHA in red cell membranes was lower in TRD than non-TRD and HC. Conclusions: Changes in levels of PUFAs in red cell membranes, but not in plasma, may be an important factor to evaluate the resistance to the pharmacological treatment.
- Subjects
ROME; UNSATURATED fatty acids; DOCOSAHEXAENOIC acid; EICOSAPENTAENOIC acid; ARACHIDONIC acid; ERYTHROCYTES; ANXIETY disorders
- Publication
European Psychiatry, 2021, Vol 64, pS323
- ISSN
0924-9338
- Publication type
Article
- DOI
10.1192/j.eurpsy.2021.868