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- Title
Change of neuropsychiatric symptomatology after novel HCV eradication treatment.
- Authors
Preve, M.; Porta, D.; Magnano, L.; Schiavone, B.; Traber, R.; Colombo, R. A.
- Abstract
Introduction: A large number of neurological complications occur in patients with chronic HCV infection and the detection of defective central serotoninergic and dopaminergic neurotransmission in some HCVpatients with neuropsychiatric symptoms has suggested a possible role for HCV in inducing dysfunction in selective aminergic systems [1,2]. Objectives: The aim of this study is to present a case report of a patient with Attention Deficit Hyperactivity Disorder and heroin dependence that after the novel treatment for the HCV eradication present a change of neuropsychiatric symptomatology with the development of psychotic spectrum disorder and suicidal plan. Methods: We present a case report and we conducted a systematic literature review with the principal scientific databases (PubMed, Embase, PsychInfo) using the key terms "HCV", "eradication", "psychiatric disorder", "psychosis", "psychomotor activation" as well as "agitation". Results: We underline the change of neuropsychiatric symptomatology with the development of psychotic spectrum disorder and intense suicidality after a HCV eradication treatment. Conclusions: HCV has been confirmed as both a hepatotropic and lymphotropic virus and the detection of defective central serotoninergic and dopaminergic neurotransmission is correrlated with HCV infection. In our case report we observe a complete change in the neuropsychiatric symptomatology, in the treatment response as well as in the severity of suicidal simptomatology. Further research is warranted to replicate our clinical and qualitative observations and, in general, quantitative studies in large samples followed up over time are needed. Methodological limitations, clinical implications and suggestions for future research directions are considered. Reference(s) [1] Evon DM, et al. 2018; [2] Adinolfi LE, et al., 2015;.
- Subjects
SYMPTOMS; ATTENTION-deficit hyperactivity disorder; SCIENCE databases; MENTAL illness; PSYCHOSES
- Publication
European Psychiatry, 2020, Vol 63, pS95
- ISSN
0924-9338
- Publication type
Article