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- Title
P02-31 - Oxidative stress and brain glutamate-mediated excitability in depressed patients
- Authors
Salustri, C.; Squitti, R.; Zappasodi, F.; Ventriglia, M.; Bevacqua, M.G.; Fontana, M.; Tecchio, F.
- Abstract
Introduction: Several neuropsychiatric pathologies have been recently linked to oxidative stress. Objectives: In this study, we investigated the relationship between depression, markers of oxidative stress and neurotransmission, as expressed by sensory cortex excitability. Methods: Serum levels of oxidative stress markers and somatosensory magnetic fields, evokedby external galvanic stimulation, were measured in 13 depressed patients and 13 controls. Results: Depressives had higher levels of total and free copper than controls and lower levels oftransferrin. They also showed lower sensory cortex excitability, which correlated with copperlevels in controls, but not in patients. Transferrin correlated with sensory cortex excitability inboth patients and controls, although in opposite ways. Copper level results associated with thepatients’ clinical status. Conclusions: Pro-oxidant agents appear to affect neuronal excitability and clinical state ofdepressed patients, as free copper excess alters their cortical glutamatergic neurotransmission.
- Subjects
OXIDATIVE stress; GLUTAMIC acid; MENTAL depression; NEUROBEHAVIORAL disorders; NEURAL transmission; MAGNETIC fields
- Publication
European Psychiatry, 2011, Vol 26, p626
- ISSN
0924-9338
- Publication type
Abstract
- DOI
10.1016/S0924-9338(11)72332-X