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- Title
B Cells and Double-Negative B Cells (CD27 − IgD −) Are Related to Acute Pancreatitis Severity.
- Authors
Malheiro, Filipa; Ângelo-Dias, Miguel; Lopes, Teresa; Azeredo-Lopes, Sofia; Martins, Catarina; Borrego, Luis Miguel
- Abstract
Acute pancreatitis (AP) is an increasingly frequent disease in which inflammation plays a crucial role. Fifty patients hospitalized with AP were included and peripheral blood samples were analyzed for B and T cell subpopulations at the time of hospitalization and 48 h after diagnosis. The Bedside Index of Severity in Acute Pancreatitis (BISAP) and length of hospital stay were also recorded. A healthy control (HC) group of 15 outpatients was included. AP patients showed higher neutrophil/lymphocyte (N/L) ratios and higher percentages of B cells than the HC group. The total B cell percentages were higher in patients with moderate/severe AP than in patients with mild AP. The percentages of B cells as well as the percentages of the CD27−IgD− B cell subset decreased from admission to 48 h after admission. The patients with higher BISAP scores showed lower percentages of peripheral lymphocytes but higher percentages of CD27−IgD− B cells. Higher BISAP scores, N/L ratios, and peripheral blood B cell levels emerged as predictors of hospital stay length in AP patients. Our findings underscore the importance of early markers for disease severity. Additionally, the N/L ratio along with the BISAP score and circulating B cell levels form a robust predictive model for hospital stay duration of AP patients.
- Subjects
B cells; T cells; PANCREATITIS; LENGTH of stay in hospitals; BLOOD cells
- Publication
Diseases, 2024, Vol 12, Issue 1, p18
- ISSN
2079-9721
- Publication type
Article
- DOI
10.3390/diseases12010018