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- Title
Design Considerations for Murine Retinal Imaging Using Scattering Angle Resolved Optical Coherence Tomography.
- Authors
Gardner, Michael R.; Katta, Nitesh; Rahman, Ayesha S.; Rylander III, Henry G.; Milner, Thomas E.
- Abstract
Featured Application: Scattering angle resolved optical coherence tomography offers a new contrast mechanism for murine retinal imaging. Optical coherence tomography (OCT), an optical imaging approach enabling cross-sectional analysis of turbid samples, is routinely used for retinal imaging in human and animal models of diseases affecting the retina. Scattering angle resolved (SAR-)OCT has previously been demonstrated as offering additional contrast in human studies, but no SAR-OCT system has been reported in detail for imaging the retinas of mice. An optical model of a mouse eye was designed and extended for validity at wavelengths of light around 1310 nm; this model was then utilized to develop a SAR-OCT design for murine retinal imaging. A Monte Carlo technique simulates light scattering from the retina, and the simulation results are confirmed with SAR-OCT images. Various images from the SAR-OCT system are presented and utility of the system is described. SAR-OCT is demonstrated as a viable and robust imaging platform to extend utility of retinal OCT imaging by incorporating scattering data into investigative ophthalmologic analysis.
- Subjects
RETINA analysis; OPTICAL coherence tomography; SCATTERING (Physics)
- Publication
Applied Sciences (2076-3417), 2018, Vol 8, Issue 11, p2159
- ISSN
2076-3417
- Publication type
Article
- DOI
10.3390/app8112159