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- Title
Antibodies to Glutamic Acid Decarboxylase in Japanese Diabetic Patients with Secondary Failure of Oral Hypoglycaemic Therapy.
- Authors
Fukui, M.; Nakano, K.; Shigeta, H.; Yoshimori, K.; Fujii, M.; Kitagawa, Y.; Mori, H.; Kajiyama, S.; Nakamura, N.; Abe, N.; Obayashi, H.; Fukui, I.; Ohta, K.; Ohta, M.; Kondo, M.
- Abstract
Some patients with non-insulin-dependent (Type 2) diabetes mellitus (NIDDM) are positive for antibodies to glutamic acid decarboxylase (anti-GAD), which have been shown to be a useful marker for the diagnosis and prediction of insulin-dependent (Type 1) diabetes mellitus (IDDM). Anti-GAD positive NIDDM patients tend to develop insulin deficiency. We investigated the prevalence of anti-GAD in 200 NIDDM with secondary failure of oral hypoglycaemic therapy (SF) and 200 NIDDM well controlled by diet and/or sulphonylurea agents (NSF). Twenty-two of 200 (11 %, p < 0.05) SF patients and 6 of 200 (3 %) NSF patients were anti-GAD positive. The positive rate for anti-GAD was as high as 23.8 % in the non-obese and insulin deficient SF patients. The SF patients with anti-GAD tended to be non-obese and to have an impaired release of endogenous insulin. The interval before development of secondary failure was not associated with the presence of anti-GAD in this study. In conclusion we found that anti-GAD was positive in as many as 11 % of the SF patients, suggesting that autoimmune mechanisms may play an important role in the pathogenesis of secondary failure of sulphonylurea therapy. © 1997 by John Wiley & Sons, Ltd.
- Publication
Diabetic Medicine, 1997, Vol 14, Issue 2, p148
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1002/(SICI)1096-9136(199702)14:2<148::AID-DIA317>3.0.CO;2-9