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- Title
Abnormal release of cardiac biomarkers in the presence of myocardial oedema evaluated by cardiac magnetic resonance after uncomplicated revascularization procedures.
- Authors
Ribas, Fernando Faglioni; Hueb, Whady; Rezende, Paulo Cury; Rochitte, Carlos Eduardo; Nomura, Cesar Higa; Villa, Alexandre Volney; Morais, Thamara Carvalho; Lima, Eduardo Gomes; Boros, Gustavo André Boeing; Ribeiro, Matheus de Oliveira Laterza; Linhares-Filho, Jaime Paula Pessoa; Dallazen, Anderson Roberto; Silva, Rafael Rocha Mol; Ramires, Jose Antonio Franchini; Kalil-Filho, Roberto
- Abstract
Aims To analyse the association of myocardial oedema (ME), observed as high T2 signal intensity (HT2) in cardiac magnetic resonance imaging, with the release of cardiac biomarkers, ventricular ejection, and clinical outcomes after revascularization. Methods and results Patients with stable coronary artery disease with the indication for revascularization were included. Biomarker levels [troponin I (cTnI) and creatine kinase MB (CK-MB)] and T2-weighted and late gadolinium enhancement (LGE) images were obtained before and after the percutaneous or surgical revascularization procedures. The association of HT2 with the levels of biomarkers, with and without LGE, evolution of left ventricular ejection fraction (LVEF), and 5-year clinical outcomes were assessed. A total of 196 patients were divided into 2 groups: Group 1 (HT2, 40) and Group 2 (no HT2, 156). Both peak cTnI (8.9 and 1.6 ng/mL) and peak CK-MB values (44.7 and 12.1 ng/mL) were significantly higher in Group 1. Based on the presence of new LGE, patients were stratified into Groups A (no HT2/LGE, 149), B (HT2, 9), C (LGE, 7), and D (both HT2/LGE, 31). The peak cTnI and CK-MB values were 1.5 and 12.0, 5.4 and 44.7, 5.0 and 18.3, and 9.8 and 42.8 ng/mL in Groups A, B, C, and D, respectively, and were significantly different. The average LVEF decreased by 4.4% in Group 1 and increased by 2.2% in Group 2 (P = 0.057). Conclusion ME after revascularization procedures was associated with increased release of cardiac necrosis biomarkers, and a trend towards a difference in LVEF, indicating a role of ME in cardiac injury after interventions.
- Subjects
BIOMARKERS; EVALUATION of medical care; VENTRICULAR ejection fraction; CARDIOMYOPATHIES; REVASCULARIZATION (Surgery); MAGNETIC resonance imaging; RESEARCH funding
- Publication
European Heart Journal - Cardiovascular Imaging, 2023, Vol 24, Issue 12, p1700
- ISSN
2047-2404
- Publication type
Article
- DOI
10.1093/ehjci/jead171