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- Title
π‐Extended BTD Derivatives: Synthesis, Photophysical Properties, and Applications in Biological Systems Imaging for Discriminating Living and Dead Cells.
- Authors
Li, Cong‐Cong; Cao, Jiaxin; Wang, Lin; Ji, Xingxiang; Xu, Yanjun; Wang, Jian‐Yong
- Abstract
Here, π‐Extended BTD derivatives were successfully synthesized by Heck coupling reaction, which exhibited the the advantages of simplicity and efficiency, wild substrate scope, easily available substrates and high yield. The fluorescent probe PEG‐BTDAr targeting LDs was successfully prepared by the nucleophilic substitution reaction between the Heck coupling reaction product 3 h and Amino polyethylene glycol monomethyl ether (Mn=2000). PEG‐BTDAr exhibited the advantages of high selectivity, good stability and pH resistance. The use of PEG as a substrate gave PEG‐BTDAr good biocompatibility. It was worth mentioning that PEG‐BTDAr could not only track LDs in cells under different physiological conditions, but also distinguish between living and dead cells in biological systems.
- Subjects
IMAGING systems in biology; HECK reaction; NUCLEOPHILIC substitution reactions; FLUORESCENT probes; BIOLOGICAL systems
- Publication
Chemistry - An Asian Journal, 2023, Vol 18, Issue 11, p1
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.202300038